STUDY ON DETERMINATION OF NIFEDIPINE IN DOG PLASMA BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRIC DETECTION
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SUMMARY
Objectives: To validate the determination method of nifedipine (NIF) in dog plasma by ultra
performance liquid chromatography with tandem mass spectrometric detection (UPLC-MS/MS).
Methods: The evaluation of the specificity, selectivity, lower limit of quantitation, accuracy,
precision, calibration curve and the linear range, recovery, carry-over, matrix effect, stability of
NIF in plasma following the guidance of US-FDA. Results: The UPLC-MS/MS method has been
evaluated and achieved the US-FDA’s regulations. Conclusion: The UPLC-MS/MS method can
be used to determine the NIF in dog plasma, which will be used in bioavailability studies of the
NIF dosage forms.
Mô tả
* Keywords: Nifedipine; UPLC-MS/MS; Dog plasma.
Năm xuất bản
2020
Tác giả
Trần Quang, Trung
Nguyễn Thanh, Hải
Trinh Văn, Lầu
Nguyễn Hữu, Duy
Nguyễn Thị, Đào
