EFFECTS OF CYP2C19 GENOTYPE ON THE ERADICATION RATE OF HELICOBACTER PYLORI INFECTION IN DUODENAL ULCER PATIENTS BY QUADRUPLE THERAPY WITH RABEPRAZOLE, BISMUTH, TETRACYCLINE AND TINIDAZOLE
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Objectives: To investigate the impact of CYP2C19 genotype on the eradication rate of
Helicobacter pylori (H. pylori) in duodenal ulcer patients by quadruple therapy with rabeprazole,
bismuth, tetracycline and tinidazole (RBTT). Subjects and methods: A total of 102 duodenal
ulcer patients infected with H. pylori completed initial treatment with 20 mg of rabeprazole
twice/day, 120 mg of bismuth subcitrate 4 times/day, 500 mg of tetracycline 4 times/day and
500 mg of tinidazole twice/day for 2 weeks. Patients were administered 20 mg of rabeprazole
twice/day for 2 weeks after the quadruple therapy. Gastroduodenalscopy was performed after
4 weeks completing the therapy to assess the treatment response. CYP2C19 genotypes were
determined with realtime polymerase chain reaction. Results: The eradication rate of H. pylori
was 91.3% (95%CI, 84.8 - 96.7%). The cure rates of H. pylori in the extensive metabolizer (EM),
intermediate metabolizer (IM), and poor metabolizer (PM) groups were 87.5%, 94.4%, and
100%, respectively. However, the genotypes of CYP2C19 were not significantly associated with
successful H. pylori eradication (p > 0.05). Conclusions: The 14-day quadruple therapy with
RBTT was effective in the H. pylori eradication. CYP2C19 genotype did not influence the
eradication of H. pylori infection.
* Keywords: CYP2C19; H. pylori eradication; Duodenal ulcer.
Mô tả
Năm xuất bản
2020
Tác giả
Nguyễn, Thanh Liêm
Trần, Việt Tú
Nguyễn, Bá Vương
Lê Thị, Thúy Loan
Nhà xuất bản
Journal of military pharmaco-medicine
